A special service will be held by campaigners and worshipers from three London churches for each of the Ripper's victims, 127 years since the Whitechapel Murders.
In August the controversial museum opened near Tower Hill, documenting the murders carried out by Jack the Ripper.
A protest will follow the service where women's groups will be joined by vicars who will light candles in silent protest, according to The East London Advertiser.
#RipperMuseum wrong on so many levels (literally - 6 floors). They have recreated his "sitting room", complete with blood spatter.
— Victorian House (@18ClarendonSq) November 11, 2015
They argue that the planning application for the museum was "misleading" and that the planning application promised "the only dedicated resource in the East End to women's history."
Christian groups are worried the museum acts more as a tribute to the killer himself, rather the female victims who were brutally murdered.
A silent march by St George's-in-the-East church will commemorate the five known victims of the 1888 murders.
This service marks the coming anniversary of the last-known Ripper victim, Mary Kelly. Her badly-mutilated body was discovered in a ground-floor tenement at Dorset Street in Spitalfields.
Supporters of the protest include the Theology Centre at St George's and London Citizens' Whitechapel HQ.
Other known victims that year were Polly Nichols, Annie Chapman and Elizabeth Stride.
Martha Tabram is thought to have been the killer's first victim.
The Bishop of Stepney Adrian Newman and Mayor of Tower Hamlets John Biggs both joined the protest in September.
As a result three churches; St George's-in-the-East, St Paul's in The Highway and St Mary's in Cable Street have planned a special roving heritage exhibition between them to honour women's achievements down the centuries in the East End.