The conference runs from Friday over the weekend and will focus on the question: "Living out our faith in the world, are we ready to meet the challenge?"
Juliet Prager, Deputy Recording Clerk for Quakers in Britain, told Premier: "We'll be thinking this year particularly about social injustice, about inequality, many Quakers are worried about the refugee situation at the moment as well as the increasing militarisation of society, so I'm sure those issues will come up."
"Quakers gather in silence, we aim to listen to God and we aim to hear God's voice and often God will speak to us."
Young people are getting more involved this year and a special time capsule has been created containing their vision for the world in 100 years' time.
The capsule will be placed in the garden at Friends House during Yearly Meeting.
Juliet Prager said: "We're going to put that in the new garden and they've chosen to put in it some peace flags, some T-shirts, books which have spiritual guidance, a solar charger and a lump of coal, and a letter from Ruth Cadbury who's a Quaker MP."
Paul Parker, Recording Clerk said everyone is looking forward to the event.
He said: "Yearly Meeting is the high-point of the Quaker year.
"It's when we come together to worship, to embolden one another in our actions in the world, and to celebrate our community.
"For me, Quakerism entails a commitment to action arising from our worship. Yearly Meeting is when we make that commitment real, together."
Listen to Premier's Hannah Tooley speak to Juliet Prager here:
