The independent review of Kendall House in Gravesend found girls as young as 11 were given anti-depressants, sedatives and anti-psychotic drugs without medical assessments.
Detailing sexual abuse, ill-treatment and physical abuse at the home between 1967 and 1986, the document also says children who refused their medication could be kept in a locked room for days on end.
Commissioned by the Bishop of Rochester Rt Revd James Langstaff last year, the 137-page report contains 19 recommendations for the Dioceses of Rochester and Canterbury, and others for the Church of England's National Safeguarding Team.
It advises the dioceses to make public apologies to all former residents for the abuse carried out at Kendall House and the delay it took to launch the independent review, given concerns were raised before the home closed in 1986.
Speaking with Premier, Bishop James said: "The treatments to which they were subjected to were completely unacceptable. That is why today I have issued an unreserved apology to the former residents of Kendall House."
The review also catalogued how some girls in Kendall House were kept in straitjackets, while the administration of drugs - which exceeded the levels usually prescribed to adults - tried to control the girls and it kept them in a constant stupor, reducing their ability to learn or communicate.
The review concludes: "The findings are harrowing. They reveal an institution which had weak governance and oversight, a place where control, containment and sometimes cruelty were normalised.
"A place where vulnerable girls, many previously and repeatedly let down by their parents, social services and other agencies, were caught in a regime that in many ways sought to rob them of their individuality, of hope, and in some cases of their liberty."
"The evidence we have heard and read during this review tells of a place which was, on the whole, toxic and constructive to the girls placed there."
The review was chaired by the woman who led the inquiry into Jimmy Savile's abuse at Leeds Teaching Hospitals, Professor Sue Proctor.
Around 20 legal claims have been brought by former-residents.
None of the perpetrators of the abuse at Kendall House remain alive.
Listen to Bishop James speaking to Premier's Marcus Jones here: