Charity World Vision said severe weather conditions have hit the region killing several people, some thought to be Christians.
It's warning money is running out to support the millions of people who are in desperate need of shelter, food and clothing.
Snow storm Zina has forced hundreds of thousands of displaced Syrians to endure freezing winter conditions.
Wynn Flaten World Vision Syria Response Director said: "We are deeply concerned for vulnerable children and families as forecasts of snowstorms are expected to sweep across the region and potentially and claim lives.
"We call upon the international community and aid agencies to urgently look into this crisis and help provide sufficient funding immediately."
The bad weather had already caused disruption in Lebanon and Jordan earlier this week.
It's thought more than 6 million children are among the affected people facing a severe food and shelter crisis in refugee camps across five countries including Jordan, Lebanon and Iraq.
The Syrian conflict is now in its fifth year and there is still no end in sight to the ongoing humanitarian crisis in the region.
United Nations figures estimate that nearly 4 million people will have registered as refugees by the end of 2014.