The Vatican has confirmed the Holy Father will go to Rebibbia Prison and a nearby women's facility in the run up to Easter.
It was the institution that held the would be assassin of Pope John Paul II, Mehmet Ali Agca, before his release in 2006.
Traditional Catholics say the Pope should only wash the feet of men since Jesus' 12 apostles were all male.
But Francis broke with this in 2013 when he invited women at a juvenile detention centre to take part.
Last year he visited a care home for the event which comes from Jesus washing the feet of his apostles.