It will be a time to remember and honour the victims of the London Bridge attacks.
The Bishop of Woolwich, The Rt Revd Karowei Dorgu, will lead an Act of Commitment and Remembrance at the service and Canon Steve Chalke will be the preacher.
The cathedral held a service last Friday in which first responders, families and survivors affected by the attack were invited.
Last week The Countess of Wessex attended the 'Service of Hope' at Southwark Cathedral following the London Bridge attack. pic.twitter.com/9NO97VsWdy
— The Royal Family (@RoyalFamily) June 21, 2017
The Dean of Southwark, the Very Revd Andrew Nunn said: "We felt that it was very important... the Cathedral should also provide an opportunity for everyone in the local community to come together and remember the events of 3 June as well as looking forward in hope."
The service is open to all and the Cathedral will open its doors at 1pm. The service will start at 2 p.m.