Tens of thousands are expected to gather for the three day conference hosted by Brian Houston.
Tonight it all starts. - Hillsong Conference Europe in the 02 centre. I love London in summer.
— Brian Houston (@BrianCHouston) August 2, 2017
Those gathered will hear from Craig Groeschel, Senior Pastor of Life.Church and New York Times best-selling author Jentezen Franklin.
Kris Mikkelson, one of the associate pastors at Hillsong London, told Premier around 13,000 people will be there on opening night with 200 churches represented.
"We've got people from all over Europe coming for praise and worship and to hear the Word," he said.
"Our theme this year is about the Holy Spirit and getting closer to God.
"It's a massive statement for that many Christians to gather."
Hillsong has been praised and also faced criticism for creating an 'performance' atmosphere at its event but Mikkelson says it's all about one thing.
"I have friends coming who don't know Jesus but they're happy to come to the o2.
"It's about salvation, whether that's tonight or whether all these churches go back fired up to build wherever they are."
Listen to Kris Mikkelson speaking to Premier's Loretta Andrews: