Rt Revd Rowan Williams, the former Archbishop of Canterbury, has written an open letter to the Observer, alongside Rabbi Laura Janner-Klausner, Miqdaad Versi and Jasvir Singh.
Together these Christian, Muslim, Jewish and Sikh leaders say "faith is about integration and building bridges, not about isolation and erecting barriers."
Ahead of the June 23rd referendum on whether Britain should remain in or leave the European Union (EU) the faith leaders are arguing an in vote representing building peace and fighting poverty .
It reads: "As leaders and senior figures of faith communities, we urge our co-religionists and other to think about the implications of a Leave vote for the things about which we are most passionate."
They argue: "Many of the challenges we face today can only be addressed in a European, and indeed a global, context: combatting poverty in the developing world, confronting climate change and providing the stability that is essential to tackling the migration crisis."
The multi-faith leaders ask whether a Leave vote could "conceivably contribute to a fairer, cleaner, safer world."
On Saturday former Labour party leader Ed Miliband stressed that young people could hand the Leave campaign what he called an "accidental victory" if young people do not sign up to vote.
But speaking on Sunday Leave campaigner Boris Johnson said that David Cameron is having a "corrosive" impact on public trust.
The Leave campaign argues that Britain can survive on its own two feet and it says the cost of being an EU member outweighs the benefits.
It says if the UK left it would be able to decide how to spend its own money and make its own laws without being overseen by Brussels.
The referendum takes place 23rd June 2016.