Major League Baseball pitcher Cole Hamels and his wife Heidi gave the property - along with 100 acres of land - located on Table Rock Lake in the US state of Missouri, to Camp Barnabas.
The Texas Rangers player said: "There are tons of amazing charities in Southwest Missouri; out of all of these, Barnabas really pulled on our heartstrings.
"Seeing the faces, hearing the laughter, reading the stories of the kids they serve; there is truly nothing like it.
"Barnabas makes dreams come true, and we felt called to help them in a big way."
During the last 24 years, Camp Barnabas has welcomed more than 75,000 people to its camps, which help young people with special needs and chronic illnesses as well as their siblings.
CEO, Jason Brawner said: "Our mission is to change lives through disability ministry, and we've been strategically looking for ways to expand our ministry outside of a summer camp.
"We have no doubt that this gift will allow us to do just that."
Cole and Heidi Hamels added: "We love that Barnabas sees the bigger picture; they are changing the way the world sees disability ministry."